Research Highlight

Caption: This image depicts the accumulation of iron oxide nanoparticles in macrophages in areas of inflammation. Although this image focuses specifically on the aorta, iron oxide nanoparticles circulate through all of the vascular system, are taken up by macrophages, and finally the reticuloendothelial system, specifically in the liver, spleen, and lymph nodes.

Assessment of neoadjuvant therapy-induced atherosclerotic changes using ferumoxytol-enhanced MR imaging

Radiation therapy can accelerate atherosclerotic changes. Macrophages and monocytes play an important role in atherosclerosis and plaque behaviors. Inflammation within these plaques can be quantitatively assessed by measuring T2* value of these plaques following intravenous administration of super paramagnetic iron oxide nanoparticles. From the cohort of pancreatic cancer patient who underwent MRI scans before and after administration of super paramagnetic iron oxide nanoparticles, we will identify two groups A)patients who underwent neoadjuvant therapy prior to undergoing these MRI scans and B)patients who did not receive neoadjuvant therapy. Quantitative T2* measurements of aortic wall and atherosclerotic plaques will be performed and compared in each group.



Trainee Research

CaNCURE provides trainees with a 6-month hands-on research experience and one-on-one mentoring by leading researchers in cancer nanomedicine.   Projects performed by current and past participants include:

Assessment of neoadjuvant therapy-induced atherosclerotic changes using ferumoxytol-enhanced MR imaging

Investigating the use of iron chelator deferoxamine (DFO)-bearing PEG-like nanoprobes as a multifunctional agent for cancer therapy and PET imaging

Iron-chelating PEG-like nanoprobes as therapeutic and 89Zr/PET imaging agents

Injectable thermogelling cisplatin-loaded hydrogels for combined chemo-radiation therapy in cervical cancer

Small T Antigen Effect on Mitotic Proteins B-Myb and FOXM1

Uptake and localization of nanoparticles in prostate and lung cancer cells as a function of time and nanoparticle type

The Assessment and Comparison of Ferumoxtran as Contrast Imaging Agent in Patients with Pancreatic Cancers.

Nanoencapsulation of tyrosine kinase inhibitors and their effects on pathway inhibition

Targeting CXCR4/SDF-1a using phytochemicals to inhibit progression and metastasis of pancreatic cancer

Development of a novel nanogel for non-invasive transdermal delivery of cancer vaccines using hyaluronic acid

Pharmacokinetic analysis of changes in temozolomide distribution after antiangiogenic treatment of glioblastoma

Digital diffraction diagnostics for lymphoma and HPV

Quantification of SPION accumulation in tumors using positive-contrast MRI

Online monitoring and image-guided treatment of chemoresistant micrometastases

Development of PSMA-targeting nanoparticles for positron emitting tomography imaging in prostate cancer using animal models

Co-delivery of antibiotics and topoisomerase inhibitors to overcome chemoresistance

Co-delivery of protective substrate and chemotherapy drugs via lipid Bilayer Mesoporous Silica Nanoparticles

Mechanistic and modeling studies of lipid nanoemulsions impact on oral lapatinib absorption

Protein-encapsulated nanoparticles for oral delivery of anti-mitotic agents in prostate cancer

Localized chemo- and chemo-radiation for the treatment of prostate cancer

Radiotherapeutic synergism of thermogelling cisplatin-loaded polymers for cervical cancer treatment

Targeting WASp using Wiskostatin-gold nanoparticles

Optimizing murine cells for in vitro modeling of high-grade serous ovarian cancer

Longitudinal assessment of tumor heterogeneity during immunotherapy for metastatic melanoma

Quantitative Multimodal Imaging of Tumor Response to Radiation

Soleil Doggett (Biology, '16) talks to her fellow peers about her research on oxygenating tumors to stimulate the anti-tumor immune response.


Trainee e-portfolios

Photo credit: Tom Kates Photography

While on co-op, trainees document their research in an e-portfolio.  This gives trainees the opportunity to provide regular updates on their research progress, reflect on training they are receiving, and explain how their research fits within the field of cancer nanomedicine.  These research e-portfolios can be accessed through individual trainee profiles.  The complete collection may be found here.

Check out this month’s featured e-portfolios by Rachel Fontana and Jordan Harris!


Presentation at CaNCURE Nanomedicine Day

At the completion of their co-op, trainees are provided with the opportunity to present their research to a wider audience.  In our 1st annual CaNCURE Nanomedicine Day, trainees prepared interactive, digital posters to display on electronic poster boards.  Over 100 faculty, students, and researchers attended our first event!

Check out the news article and congrats to all the poster winners!

Jordan Harris: Most Innovative Cancer Research Award
Jeremy Thong: Best Undergraduate Research Poster Award
Craig Pille: Most Promising Translational Research Award
Bryan Kynnap: Most Promising Basic Science Award
Jordan Harris: Top Chemical Engineering Poster Award