Emerging Nanoscale Systems in Drug Delivery: It’s All About Delivery

The nano-scale systems are predicted to have an enormous impact on next-generation health care technologies such as point-of-care diagnostics and ligand-receptor-mediated drug delivery. This presentation will highlight a progression of drug delivery strategies to address clinically challenging problems, where efforts are directed towards customizing needs for the drug and the disease in question. We have a special interest in the study of nanoscale systems for oral drug delivery of poorly soluble and permeable compounds. Recently, we have developed the next-generation non-competitive active delivery systems. In order to achieve non-competitive targeting we have used gambogic acid (GA), a small molecule pigment of gamboge resin, as a targeting ligand for the transferrin receptor (TfR), a target receptor expressed at high levels in the small intestine barriers. Our recent work involved the synthesis of precision-polyesters (P2s) for ligand-receptor stoichiometry optimization and develops a comprehensive toolbox to allow for controlled access of desired structures. The significant body of data over the years not only provides a strong basis for a new paradigm in nanomedicine research, but will also open up novel, broadly applicable, and clinically relevant regimens for various diseases and associated complications. The success of ongoing projects will further open up new avenues in receptor mediated oral delivery of difficult to deliver compounds that constitute about 40% of the new chemical entities requiring specialized delivery systems.

Dr. Ravi Kumar received his PhD in Drug Delivery from Indian Institute of Technology, Roorkee, in 2000. Prior to joining Texas A&M University as a Professor of Pharmaceutics in 11/2013, he was a tenured full professor at University of Strathclyde, Glasgow-UK, and Assistant Professor at National Institute of Pharmaceutical Education and Research, India. His research in drug delivery has won him numerous awards including the T. Nagai (Controlled Release Society, USA) outstanding researcher advisor, in recognition of excellent leadership and mentorship (2018), British Pharmaceutical Conference Science Medal, UK (2009), Tom Gibson Memorial Award by British Society of Plastic Surgeons & the Royal College of Physicians and Surgeons, UK (2008), Indian National Science Academy (INSA) Medal for Young Scientist, India (2007) and he was awarded Alexander von Humboldt Research Fellowship, Germany (2002). He is elected a Fellow of American Association of Pharmaceutical Scientists (AAPS) [2018].