Nanomedicine in Cardiovascular Imaging
The use of small molecules, such as radio-tracers and gadolinium chelates, in cardiovascular imaging is routine. While the kinetics and safety of these agents are very favorable, they suffer from several limitations. Nanoparticles offer the opportunity to overcome many of these limitations but also pose many challenges. In this brief lecture I will review the recent experience with targeted and activatable nanoparticles for cardiovascular imaging. Particular emphasis will be placed on the use of super-paramagnetic nanoparticles and near infrared fluorochromes.
David Sosnovik, MD, is an Associate Professor of Medicine Harvard Medical School and Director of the Program in Cardiovascular Imaging in the Martinos Center for Biomedical Imaging at MGH. His research focuses on the molecular imaging of processes involved in myocardial injury and repair, including imaging of cardiomyocyte apoptosis, myocardial inflammation (both acute and chronic injury models), and stem cell therapy in infarcted myocardium. He has shown recently that cardiomyocyte apoptosis can be imaged in-vivo, by MRI, in the rapidly beating heart of a live mouse. To the best of our knowledge, this has been the first successful demonstration of targeted molecular imaging, by MRI, in the myocardium in-vivo.