Three-dimensional Bioprinting for Tissue/Organ Regeneration
Three-dimensional (3D) bioprinting is a group of rapidly growing technology that haspotential applications in tissue engineering and regenerative medicine. This technology allows the precise placement of cells, biomolecules and biomaterials in spatially predefined locations within confined 3D structures, therefore achieving recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Bioprinting technologies are classified into three main categories, inkjet-based bioprinting, extrusion-based bioprinting and laser-based bioprinting, based on the underlying printing principles. Biomaterial parameters such as biocompatibility, cell viability and the cellular microenvironment strongly influence the bioprinted tissue scaffolds. Various bioprinting technologies and biomaterials have been investigated for printing various types of tissue, including vasculature, heart, bone, cartilage, skin and liver. In this lecture series, we will discuss basic principles and key aspects of commonly used 3D bioprinting technologies and provide an overview of recent advances in 3D bioprinting technology, as well as design of bioinks suitable for the bioprinting process. We will conclude with current challenges and the future perspectives for further development of 3D organ bioprinting.
Dr. Sushila Maharjan is a research scholar at Brigham and Women’s Hospital. Dr. Maharjan received her Ph.D. in Biochemistry from Sun Moon University, Korea, Master’s degree in Chemistry and Bachelor’s degree in Biological Sciences, both from Tribhuvan University, Nepal. She has extensive research experience in diverse fields including molecular biology and biotechnology, metabolic and genetic engineering, drug and vaccine delivery, and biomaterial and tissue engineering. She has contributed over 30 articles in peer-reviewed international journals and 2 book chapters. Dr. Maharjan’s exemplary achievements in research have been recognized by prestigious “Elsevier Foundation Awards for Early Career Women Scientists, 2016” and “Best Poster Award, Korean Society of Glycobiology 2011”. She has also received several fellowships and research grants including “American Fund for Alternatives to Animal Research fellowship 2016”, “Brain Korea 21 PLUS fellowship 2015”, TWAS Research Grants in Basic Sciences 2013,”, Korean Research Fund Scholarship 2007- 2010″, and Sun Moon University PhD fellowship 2006.