Synergistic Antibacterial Mechanism of Combined Silver Nanoparticles and Conventional Antibiotics

Thursday, October 19, 2017 2:50 PM

posted in: Joint IGERT Nanomedicine and CaNCURE Seminar

A combination of silver nanoparticles (AgNPs) and an antibiotic can synergistically inhibit bacterial growth, especially against the drug-resistant bacteria Salmonella typhimurium. However, the mechanism for the synergistic activity is not known. This study chooses four classes of antibiotics, β-lactam (ampicillin and penicillin), quinolone (enoxacin), aminoglycoside (kanamycin and neomycin), and polykeptide (tetracycline) to explore their synergistic […]

In Vivo Imaging Guides Prediction and Optimization of Nanomedicine Action in Cancer

Friday, October 20, 2017 3:25 PM

posted in: Joint IGERT Nanomedicine and CaNCURE Seminar

Drug-loaded therapeutic nanoparticles have been developed to deliver drugs more safely and effectively to tumors.  In principle, the “enhanced permeability and retention” (EPR) effect operates to improve selective tumoral nanomedicine delivery via features including hyper-permeable tumor vasculature and dysfunctional lymphatics; however, in practice, EPR effects are often heterogeneous across tumors and patients, and consequently have […]

Blood trails: nanotechnology-enabled biomarker quantification for early disease detection

Friday, October 13, 2017 3:25 PM

posted in: Joint IGERT Nanomedicine and CaNCURE Seminar

Dr. Tony Hu’s research focuses on developing and validating integrated nanotechnique-based strategies for marker discovery and molecular diagnostics in peripheral blood samples to provide a translatable solution for personalized medicine. His innovations aim to fill current gaps in early detection, real-time therapy monitoring and effective prognostics. Instead of competing on lowering the detection limit of […]