Progress Towards Rational Cancer Therapy

Friday, November 10, 2017 3:25 PM

posted in: Joint IGERT Nanomedicine and CaNCURE Seminar

Dr. Zdravka Medarova Associate Professor in Radiology, Harvard Medical School   Progress Towards Rational Cancer Therapy Over 90% of deaths from cancer are, in fact, due to metastasis and not the primary tumor. However, development of cancer therapeutics is traditionally focused on the primary tumor, which is partly the reason behind the poor outcomes in […]

Nanomedicine in Cancer

Friday, November 3, 2017 3:25 PM

posted in: Joint IGERT Nanomedicine and CaNCURE Seminar

Karen Liby, Ph.D. Associate Professor at Pharmacology & Toxicology, Michigan State University   Despite tremendous progress in our understanding of the biology of cancer, the translation of these advances into a clinical benefit has not kept pace, as the number of deaths from cancer remain unacceptably high. However, rapid advancements in nanomedicine provide opportunities to […]

Tuning Polymeric Nanoparticles for Efficient Gene Delivery

Thursday, October 26, 2017 2:50 PM

posted in: Joint IGERT Nanomedicine and CaNCURE Seminar

Bijay Singh, Ph.D. Postdoctoral Research Associate, Northeastern University Tuning Polymeric Nanoparticles for Efficient Gene Delivery Polymeric nanoparticles for gene delivery can enter the cells through different endocytic pathways and get trapped in endosomes. Hence, the release of DNA from endosomes, that is, endosomal escape prior to their degradation in lysosomes, appears to be a major […]

Biomedical Applications of Magnetic Nanoparticles: Remote Control of Cells

Friday, October 27, 2017 3:25 PM

posted in: Joint IGERT Nanomedicine and CaNCURE Seminar

Jon Dobson, Ph.D. J. Crayton Pruitt Family Department of Biomedical Engineering & Department of Materials Science and Engineering, University of Florida The use of magnetic micro‐ and nanoparticles for biomedical applications was first proposed in the 1920s as a way to measure the rheological properties of the cytoplasm. Since that time, particle synthesis techniques and […]

Synergistic Antibacterial Mechanism of Combined Silver Nanoparticles and Conventional Antibiotics

Thursday, October 19, 2017 2:50 PM

posted in: Joint IGERT Nanomedicine and CaNCURE Seminar

Hongtao Yu, Ph.D. Dean and Professor of Chemistry, Morgan State University A combination of silver nanoparticles (AgNPs) and an antibiotic can synergistically inhibit bacterial growth, especially against the drug-resistant bacteria Salmonella typhimurium. However, the mechanism for the synergistic activity is not known. This study chooses four classes of antibiotics, β-lactam (ampicillin and penicillin), quinolone (enoxacin), […]

In Vivo Imaging Guides Prediction and Optimization of Nanomedicine Action in Cancer

Friday, October 20, 2017 3:25 PM

posted in: Joint IGERT Nanomedicine and CaNCURE Seminar

Dr. Miles Miller Assistant Professor of Radiology, MGH Drug-loaded therapeutic nanoparticles have been developed to deliver drugs more safely and effectively to tumors.  In principle, the “enhanced permeability and retention” (EPR) effect operates to improve selective tumoral nanomedicine delivery via features including hyper-permeable tumor vasculature and dysfunctional lymphatics; however, in practice, EPR effects are often […]