CaNCURE Mentors

Zdravka Medarova, Ph.D.

Associate Professor in Radiology
Martinos Center for Biomedical Imaging

Biography: Dr. Zdravka Medrova is Assistant Professor of Radiology in Harvard Medical School and Assistant in Neuroimaging, Massachusetts General Hospital. She is a member of International Society for Magnetic Resonance in Medicine. Dr. Medarova was born in Bulgaria, E.U. and received her B.A. summa cum laude, Pre-med, from University of Southern Maine, and, Ph.D. summa cum laude in Genetics from University of New Hampshire. Her postdoctoral training was at Massachusetts General Hospital as Research Fellow in Radiology.

Research and Expertise: The focus of my research has been the development and testing of multi-functional imaging/delivery vehicles for combined cancer imaging and therapy. My earliest work described, for the first time, the design and application of ultrasmall iron oxide nanoparticles as imaging-capable carriers of siRNA to tumors. This work generated substantial interest in the research community, since it illustrated the value of these nanoparticles for the delivery of small RNA therapy to challenging organ targets and also described an approach for the noninvasive monitoring of small RNA delivery. More recently, our lab developed magnetic nanoparticles as delivery vehicles of miRNA-targeted therapy to breast tumors. These general research areas laid the groundwork for the proposed research by establishing the feasibility of delivering oligonucleotide probes to tumor cells and by developing a method for targeted nanoparticle delivery. The current application builds logically on my prior work, yet its focus is conceptually novel.



Featured Publications



SiRNA nanocomplexes