CaNCURE Mentors

Zdravka Medarova, Ph.D.

Associate Professor in Radiology
Martinos Center for Biomedical Imaging

Biography: Zdravka Medarova is an Associate Professor in Radiology at Harvard Medical School and Assistant at the Massachusetts General Hospital. Dr. Medarova holds a B.A. in pre-medicine from the University of Southern Main, and a Ph.D. in Genetics from the University of New Hampshire. Her postdoctoral training was at the Massachusetts General Hospital and Harvard Medical School.

Research and Expertise: Dr. Medarova's interests fall within the realm of miRNA-targeted cancer therapy. Her team described, for the first time, the design and application of ultrasmall iron oxide nanoparticles as imaging-capable carriers of siRNA to tumors. This work generated substantial interest in the research community, since it illustrated the value of these nanoparticles for the delivery of small RNA therapy to challenging organ targets and also described an approach for the noninvasive monitoring of small RNA delivery. The latter property was particularly novel and important at the time, considering the overall lack of direct knowledge about the bioavailability of small RNA after in vivo delivery and the crucial relevance of adequate delivery to therapeutic success. More recenty, Dr. Medarova’s team focused on the development of miRNA-targeted therapy for metastatic disease.



Featured Publications



SiRNA nanocomplexes