CaNCURE Mentors

Paul Vouros, Ph.D.

Professor of Chemistry
Northeastern University

Biography: Dr. Paul Vouros is a Professor of Chemistry and Chemical Biology and Senior Faculty Fellow in the Barnett Institute, Northeastern University, who is experienced in trace detection of DNA adducts by direct analysis. Dr. Vouros obtained a B.S. in chemistry from Wesleyan University in 1961, a Ph.D. in chemistry from MIT in 1965, and trained at Institute for Lipid Research and Department of Biochemistry, Baylor College of Medicine, before joining Northeastern University in 1974. He is a Subject Editor for Mass Spectrometry Reviews, and Chairman of the Scientific Advisory Board Mass Spectrometry Facility for Boston University Medical School. Dr. Vouros has authored over 215 publications.

Research and Expertise: The central focus of our research is in the area of mass spectrometry and its applications to organic analysis. Our efforts involve the investigation of both fundamental and applied problems. We have established a strong reputation for the development of techniques that involve the interfacing of separation methods – gas chromatography, liquid chromatography, and capillary zone electrophoresis – with mass spectrometry. Optimization of these sample delivery systems has enabled us to advance the state of the art for trace level analysis of biological samples. Much of our applied work is being done in collaboration with colleagues from the biomedical community in the Greater Boston area and beyond. As a result of the commitment of the program to the solution of real life analytical problems, a number of active collaborations with clinicians and other biomedical colleagues both in the Boston area and nationally have been initiated. Some of the main areas of investigation include the following: analysis of DNA adducts through development of techniques for the trace level detection and characterization of modified nucleosides or nucleotides as a result of the covalent binding of carcinogens with DNA; applying LC-MS and GC-MS to study the metabolic pathways of vitamin D; characterization and sequencing of oligosaccharides by ion trap MS; and studies in capillary electrochrom



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