CaNCURE Mentors


William S Hancock, Ph.D.


Professor of Chemistry
Northeastern University



Our lab is focused on advanced protein characterization methods for the study of cancer mechanisms and discovery of potential therapeutic agents. Students will use a nanoLC/MS coupled to a LTQ-Orbitrap to identify glycoprotein biomarkers and protein therapeutics.


wi.hancock@neu.edu

Biography: Prof. Hancock is the founding Editor-in-Chief of the ACS publication, Journal of Proteomic Research, which is a leading journal publishing research in related areas of functional genomics, proteomic methodological research, disease and agricultural proteomics as well as metabanomics. Dr. Hancock has published over 260 scientific publications and 7 books, holds 15 patents, and has organized and lectured in numerous international meetings. Dr. Hancock has received a number of honors, including the Martin Gold Medal in Separation Science (British Chromatographic Society), Stephen dal Nogare Memorial Award in Chromatography, the ACS Award in Chromatography and served as co-chair of the NCI Alliance of Glycan markers for the early detection of cancer. He is Past-President of US-HUPO (human proteome organization) and Vice President on the International HUPO council. From 2009-13 he was a WCU professor at Yonsei University, Seoul and in collaboration with Dr. Young-Ki Paik developed a chromosome centric proteomic project and lead a team that is studying the protein parts list of chromosome 17 including the erbb2 gene environment in development of breast, stomach and colon cancer. From 2010-13 he was adjunct Professor of Clinical Proteomics at Macquarie University, Sydney.

Research and Expertise: Prof. Hancock’s research is focused on applying new analytical technology to current problems in the biotechnology industry as well as cancer proteomics and the plasma proteome. In the area of biotechnology his focus in the area of new mass spectrometric methods to characterize protein structure, with emphasis on glycosylation and disulfide linkages, and PK/ metabolism studies, which includes the DARPA funded production of protein pharmaceuticals in an innovative MIT collaboration. Also Prof. Hancock is a co-leader of an international, collaborative initiative called the chromosome-centric human proteome project (C-HPP) which has enlisted 24 national teams, each focusing their efforts on the proteins contained on a single chromosome — each of which contains hundreds to thousands of genes. Also Dr. Hancock’s team, which includes Stanford, Michigan and Manitoba University, will characterize the proteins on chromosome number 17, including the important breast cancer gene, ERBB2. Ultimately, the goal is to have a full protein database within ten years, which will help clinicians analyze a patient’s true biological state and design targeted therapies for their conditions. In 2012,3 the Journal of Proteome Research published two special issues which contained 75 papers describing progress by the chromosome issue and the discovery of missing proteins on all chromosomes.

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