Umar Mahmood, M.D.
Vice Chair for Precision Imaging, Department of Radiology
Professor of Radiology
Biography: Dr. Mahmood earned his bachelor’s degree from the California Institute of Technology, and his medical degree and doctorate in biophysics and physiology from Cornell University. His doctoral and postdoctoral work at Memorial Sloan Kettering Cancer Center focused on tumor energetics and membrane physiology, studied using 31P nuclear magnetic resonance spectroscopy. He completed his radiology residency at MGH in 2001 and has maintained faculty appointments at MGH and Harvard Medical School since. During his more than 20 years at MGH, he has conducted PET, optical and MR imaging research, and has focused on translational efforts to better understand drivers of cancer, including the tumor microenvironment, cancer signaling pathways, changes in cancer metabolism, and the interaction of the immune system with tumors. Dr. Mahmood is vice chair for precision imaging in the Department of Radiology at Massachusetts General Hospital (MGH) and professor of radiology at Harvard Medical School in Boston. An accomplished researcher, he has received more than $20 million in grant funding as principal investigator, primarily from the National Institutes of Health (NIH), for his research into the applications of molecular imaging to guide precision medicine, particularly in developing and applying positron emission tomography (PET) and optical imaging technologies for disease characterization and therapy optimization.
Research and Expertise: I have been actively involved for more than two decades in developing and implementing new imaging methods for examination of disease processes, with a focus on translatable technology and early therapeutic response assessment. I am interested in the early phases of translation of new radiopharmaceuticals or novel applications of approved agents to develop and improve such readouts. I have a long standing interest in the tumor microenvironment, cell surface receptors, and metabolic alterations; imaging processes in cardiovascular disease; and imaging targets in autoimmune disease, evaluated using PET, SPECT, optical, and MR methods.