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Nathan McDannold, Ph.D.


Associate Professor, Radiology
Brigham And Women's Hospital


Associate Professor, Radiology
Harvard Medical School


NJM@BWH.HARVARD.EDU

Biography: Nathan McDannold, PhD, has put tremendous effort into the brain applications of focused ultrasound and worked with Kullervo Hynynen to become one of the first to open the blood-brain barrier. His work in drug delivery and neurodegenerative diseases is sure to change the way that medicine is practiced. A medical physicist, he has been a participant in the care of every focused ultrasound patient treated at BWH since 1996.

Research and Expertise: My laboratory investigates therapeutic uses of ultrasound. Ultrasound, which can be focused deep into the body can be used for a wide range of therapies. Most of my work is centered on using it as a noninvasive tool for ablating tumors or for temporarily modifying vascular barriers to enhance the delivery of drugs. We are particularly interested in the brain, and have been working for years on using focused ultrasound and microbubbles to disrupt the blood-brain barrier. In addition to these basic works, I also have a strong interest in developing imaging methods to guide and monitor focused ultrasound therapies and am closely involved with tumor ablation clinical trials at BWH.

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