In the past, severe soft-tissue trauma and bone loss resulting from injuries in limbs have often been treated with primary amputation. Limb salvage surgery is now possible for these injuries with advancements in soft tissue coverage and nerve repair techniques. High infection rates and erratic bony healing may also result from high-energy extremity trauma—it is often quite challenging to repair these bony defects while maintaining an environment that prevents infection. However, nanomedicine presents itself as a viable solution in combating bacterial infection and increasing the efficacy of the bone healing process. Nanoparticles can be engineered to serve a variety of functions that can aid in the treatment of high-energy extremity trauma. Developed particles are able to target bacteria via surface charge, leading to the controlled release of antibiotics, to encapsulate growth factors (bone morphogenic proteins) for transport to targeted bone and bone matrix material, and to target collagen for the delivery of anti-inflammatory agents. The goal of this work is to develop a single nanostructure platform capable targeting bacteria and releasing a cocktail of treatment drugs.
CaNCURE provides trainees with a 6-month hands-on research experience and one-on-one mentoring by leading researchers in cancer nanomedicine. Projects performed by current and past participants include:
While on co-op, trainees document their research in an e-portfolio. This gives trainees the opportunity to provide regular updates on their research progress, reflect on training they are receiving, and explain how their research fits within the field of cancer nanomedicine. These research e-portfolios can be accessed through individual trainee profiles. The complete collection may be found here.
Presentation at CaNCURE Nanomedicine Day
At the completion of their co-op, trainees are provided with the opportunity to present their research to a wider audience. In our 1st annual CaNCURE Nanomedicine Day, trainees prepared interactive, digital posters to display on electronic poster boards. Over 100 faculty, students, and researchers attended our first event!
Check out the news article and congrats to all the poster winners!
Jordan Harris: Most Innovative Cancer Research Award
Jeremy Thong: Best Undergraduate Research Poster Award
Craig Pille: Most Promising Translational Research Award
Bryan Kynnap: Most Promising Basic Science Award
Jordan Harris: Top Chemical Engineering Poster Award