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Christina Flavin

Mechanical Engineering, '20


Assessment of Atherosclerotic Changes using Ferumoxytol as MRI Contrast Agent

Mentor: Mukesh Harisinghani, MD (MGH)

Atherosclerosis is a degenerative disease of the arteries, resulting in plaque build up eventually causing significant cardiovascular diseases such as stroke and myocardial infraction. In cancer patients, the atherosclerotic progress can be accelerated due to radiation therapy. This process starts in the vascular wall with accumulation of pro inflammatory macrophages, considered as predecessor of atherosclerosis. We intend to evaluate these changes using MRI by exploring T2* values of carotid walls before and after the administration of a surrogate marker ferumoxytol: an ultrasmall superparagmagnetic iron oxide nanoparticle in thyroid cancer patients.