Northeastern University

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

Kong, N., Tao, W., Ling, X., Wang, J., Xiao, Y., Shi, S., Ji, X., Shajii, A., Gan, S.T., Na Yoon Kim, Duda, D.G., Xie, T., Omid C Farokhzad, Jinjun Shi, 2019. “Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53 -deficient cancers to mTOR inhibition”. Sci. Transl. Med. 2019 Dec 18;11(523):eaaw1565. PMCID: PMC7024563