Merkel Cell Carcinoma (MCC) is a rare and aggressive skin cancer with a high rate of metastasis and death. Though MCC itself is quite rare, Merkel cell polyomavirus (MCPyV) is found in a large percentage of the human population. Furthermore, it has been found that 80% of MCCs are positive for MCPyV. Polyomaviruses are characterized by their non-enveloped double stranded DNA that code for both large and small T proteins. The small T antigen is commonly associated with the upregulation of late cell cycle genes (G2/M phase). Similarly, N-MYC and C-MYC are genes which are believed to regulate FOXM1 and B-Myb respectively. Both are part of a protein complex that pushes cells into mitosis. My research will also involve the introduction of the aniPOND technique to the lab. AniPOND is essentially the inverse of ChIP-Sequencing. By pulling down the DNA and looking at the proteins attached using aniPOND, I will investigate small T’s effect on FOXM1 and B-Myb.