Northeastern University

Characterization of Nanoparticle Uptake in the Nano-SMART Clinical Trial

Mentor: Ross Berbeco, Ph.D.

Institution: Dana Farber Cancer Institute

As a research assistant for six months in the Berbeco Lab, I will be on the NANO-SMART project. Focusing on the specific AGuIX nanoparticle (Albumin-Gadolinium-Diethylene Triamine Pentaacetic Acid-Polyethylene Glycol-coated Iron Oxide), it has been developed for medical applications, particularly in the field of cancer treatment. AGuIX nanoparticles are designed to be used as contrast agents for medical imaging techniques, such as magnetic resonance imaging (MRI), and as therapeutic agents for targeted cancer therapy. The project involves a clinical trial component and data analysis factor, in which the first month and half involves training on the MIM software. Protocols and training for the data analysis component will be applied to accomplish the following: general navigation, finding new patients, countouring, bias corrections, and registering images. Throughout the remaining months, I will be focusing on performing these skills on data and organizing the findings utilizing Excel and Epic. Furthermore, graphs and charts will be created to establish concrete findings and relationships about the nanoparticle and its’ effect on pancreatic cancer patients. As a continuous data analysis project, I am also going to shadow the clinical research team to gain new experience in patient care and team communication. This project will allow us to explore the AGuIX nanoparticle and its’ affect on pancreatic and lung tumors to further implement in cancer treatment. 

CaNCURE Research Presentation: https://youtu.be/u2Q1f_bCqa8